In collaboration with colleagues at Washington University, St. Louis, Dr. Doug Kwon and associates characterized the viruses and bacteria in the intestines of individuals with progressive HIV infection. They show that the phylogenetic diversity and abundance of viruses and bacteria in these individuals differ from controls, with increased abundance of certain bacteria that have been... Read More

Using transposon-insertion sequencing, Dr. Waldor and colleagues identified genes of V. parahaemolyticus, the most common cause of seafood-borne gastroenteritis, that contribute to viability of the pathogen in vitro and in the mammalian small intestine. They show that the V. parahaemolyticus toxR locus is required for fitness of the pathogen in animals. ToxR is required because... Read More

The ways in which tuberculosis synthesizes, degrades, and transports lipids is critical to the pathogen’s growth in an infected host. Dr. Eric Rubin and colleagues show that two genes involved in transport of the lipid triacylglyceride. These genes are required for regulation of bacterial growth and metabolism during infection of mice. The requirement for these... Read More

A major goal for HIV treatment is sustained antiretroviral therapy-free HIV remission. Critical to the analysis of potential therapeutic approaches for treatment interruption is the identification of biomarkers that predict the time to viral rebound after treatment interruption. Drs. Li, Gandhi, and colleagues show that higher pre-analytic treatment interruption cell-associated HIV RNA levels were significantly... Read More