Alterations in the human virome and bacterial microbiome associated with immunodeficiency in progressive HIV infection

In collaboration with colleagues at Washington University, St. Louis, Dr. Doug Kwon and associates characterized the viruses and bacteria in the intestines of individuals with progressive HIV infection. They show that the phylogenetic diversity and abundance of viruses and bacteria in these individuals differ from controls, with increased abundance of certain bacteria that have been associated with increased inflammation. The investigators postulate that the observed differences may contribute to AIDS-associated enteropathy and disease progression. Monaco CL, et al, Cell Host Microbe 2016.

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