The ways in which tuberculosis synthesizes, degrades, and transports lipids is critical to the pathogen’s growth in an infected host. Dr. Eric Rubin and colleagues show that two genes involved in transport of the lipid triacylglyceride. These genes are required for regulation of bacterial growth and metabolism during infection of mice. The requirement for these genes during infection suggest that the proteins they encode, as well as other regulators of metabolism during infection, represent potential targets for new therapeutics. Martinot AJ, et al, PLoS Pathog 2016.
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